ncRNA name | circHIPK3 |
ncRNA Category | circRNA |
Disease name | age-related cataract |
Species | Homo sapiens |
Tissues/Cell_line | lens epithelium samples; human lens epithelial cells (HLECs) |
Methods | circRNA sequencing, qRT-PCR, transfection, MTT assay, Calcein-AM and PI staining, Rhodamine 123 and Hoechst 33342 staining, EdU incorporation assay, luciferase reporter assay, Western blot |
Expression pattern | down-regulated |
Functional description | One highly conserved circRNA, circHIPK3, is significantly down-regulated in all cortical, nuclear and posterior subcapsular subtypes of ARC. CircHIPK3 regulates HLECs function through miR-193a-mediated CRYAA expression. |
PubMed ID | 29959922 |
Year | 2018 |
Title | Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis. |
Drug-related ncRNA | NA |
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